Biochemical assay for AD7C-NTP in urine as an Alzheimer's disease marker
نویسندگان
چکیده
منابع مشابه
Clinical study of a urinary competitve ELISA for neural thread protein in Alzheimer disease.
AD7C-NTP (neural thread protein) is a approximately 41-kD brain protein that is selectively elevated in Alzheimer disease (AD). AD7C-NTP is associated with the pathologic changes of AD, and overexpression of the AD7C-NTP gene is associated with cell death similar to that found in the AD brain. A newly developed competitive ELISA (enzyme-linked immunosorbent assay) was tested in urine samples fr...
متن کاملUrine AD7c-NTP Predicts Amyloid Deposition and Symptom of Agitation in Patients with Alzheimer’s Disease and Mild Cognitive Impairment
BACKGROUND Expression of neuronal thread protein (NTP), which is considered to be related to neuritic sprouting and neuronal death, may be elevated in brain tissue, cerebrospinal fluid, and even urine in patients with Alzheimer's disease (AD). OBJECTIVE In this study, we analyzed the correlation between urine AD-associated NTP (AD7c-NTP) level, and amyloid-β (Aβ) deposition, and clinical symp...
متن کاملThe AD7c-NTP neuronal thread protein biomarker for detecting Alzheimer's disease.
Dementia in Alzheimer's disease (AD) is ultimately due to cell loss mediated by several mechanisms including, apoptosis, impaired mitochondrial function, and possibly necrosis. A second major neuroanatomic correlate of dementia is aberrant cortical neuritic sprouting with abundant proliferation of dystrophic neurites. Early in vivo detection of AD will require non-invasive assays of highly sens...
متن کاملDoes the AD7c-NTP locus encode a protein?
AD7c-NTP, the only known protein entirely encoded by tandem and nested cassettes of Alu repetitive elements, is reportedly over-expressed in brains of Alzheimer's disease patients [de la Monte et al., J. Clin. Invest. 15 (1997)]. Based on these findings a commercial diagnostic assay ("7c Gold"/"AlzheimAlert" ) has been developed. We analyzed the published cDNA sequence and compared it to corres...
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ژورنال
عنوان ژورنال: Journal of Clinical Laboratory Analysis
سال: 1998
ISSN: 0887-8013,1098-2825
DOI: 10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5